CCM2 (NM_031443) Human Mass Spec Standard
CAT#: PH301418
CCM2 MS Standard C13 and N15-labeled recombinant protein (NP_113631)
Specifications
Product Data | |
Tag | C-Myc/DDK |
Species | Human |
Expression Host | HEK293 |
Expression cDNA Clone or AA Sequence | RC201418 |
Predicted MW | 48.8 kDa |
Protein Sequence |
>RC201418 protein sequence
Red=Cloning site Green=Tags(s) MEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKYL GQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVLSLSAYNVKLAWRDGEDIILRVPIHDIA AVSYVRDDAAHLVVLKTAQDPGISPSQSLCAESSRGLSAGSLSESAVGPVEACCLVILAAESKVAAEELC CLLGQVFQVVYTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDIKETYEVEASTFCFPESVDVGGAS PHSKTISESELSASATELLQDYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEFCINLRQLYGDSRKFLL LGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRHRRALSTTSSSTTNGNRATGSSDDRSAPSEGDE WDRMISDISSDIEALGCSMDQDSA TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration | 50 ug/ml as determined by BCA |
Labeling Method | Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine |
Buffer | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. Store at -80°C. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions. |
Reference Data | |
RefSeq | NP_113631 |
RefSeq Size | 1904 |
RefSeq ORF | 1332 |
Synonyms | C7orf22; OSM; PP10187 |
Locus ID | 83605 |
UniProt ID | Q9BSQ5 |
Cytogenetics | 7p13 |
Summary | This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009] |
Documents
FAQs |
Resources
Recombinant Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC410516 | CCM2 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LC422467 | CCM2 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 187.00 |
|
LC425504 | CCM2 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LC432927 | CCM2 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LC432976 | CCM2 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LY410516 | Transient overexpression lysate of cerebral cavernous malformation 2 (CCM2), transcript variant 2 |
USD 396.00 |
|
LY422467 | Transient overexpression lysate of cerebral cavernous malformation 2 (CCM2), transcript variant 1 |
USD 605.00 |
|
LY425504 | Transient overexpression lysate of cerebral cavernous malformation 2 (CCM2), transcript variant 1 |
USD 396.00 |
|
LY432927 | Transient overexpression lysate of cerebral cavernous malformation 2 (CCM2), transcript variant 4 |
USD 396.00 |
|
LY432976 | Transient overexpression lysate of cerebral cavernous malformation 2 (CCM2), transcript variant 3 |
USD 396.00 |
|
TP301418 | Recombinant protein of human cerebral cavernous malformation 2 (CCM2), transcript variant 2 |
USD 867.00 |
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