Livin (BIRC7) (NM_139317) Human Mass Spec Standard

CAT#: PH304906

BIRC7 MS Standard C13 and N15-labeled recombinant protein (NP_647478)

Product Images

Coomassie blue staining of purified BIRC7 protein (Cat# TP304906). The protein was produced from HEK293T cells transfected with BIRC7 cDNA clone (Cat# RC204906) using MegaTran 2.0 (Cat# TT210002).

Specifications

Product Data

• Tag: C-Myc/DDK
• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence: RC204906
• Predicted MW: 32.8 kDa
• Protein Sequence:
  Sequence Link

  >RC204906 protein sequence
  Red=Cloning site Green=Tags(s)
  
  MGPKDSAKCLHRGPQPSHWAAGDGPTQERCGPRSLGSPVLGLDTCRAWDHVDGQILGQLRPLTEEEEEEG
  AGATLSRGPAFPGMGSEELRLASFYDWPLTAEVPPELLAAAGFFHTGHQDKVRCFFCYGGLQSWKRGDDP
  WTEHAKWFPSCQFLLRSKGRDFVHSVQETHSQLLGSWDPWEEPEDAAPVAPSVPASGYPELPTPRREVQS
  ESAQEPGGVSPAQAQRAWWVLEPPGARDVEAQLRRLQEERTCKVCLDRAVSIVFVPCGHLVCAECAPGLQ
  LCPICRAPVRSRVRTFLS
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: 50 ug/ml as determined by BCA
• Labeling Method: Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
• Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3. Store at -80°C. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.

Reference Data

• RefSeq: NP_647478
• RefSeq Size: 1386
• RefSeq ORF: 894
• Synonyms: KIAP; LIVIN; ML-IAP; MLIAP; RNF50
• Locus ID: 79444
• UniProt ID: Q96CA5
• Cytogenetics: 20q13.33
• Summary: This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jul 2013]
• Protein Families: Druggable Genome