Alpha-Synuclein / SNCA (A30P/A53T Mutant) Human Protein

CAT#: SA6003X

Alpha-Synuclein / SNCA (A30P/A53T Mutant) human protein, 0.5 mg

Product Images

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Predicted MW: 14.516 kDa
• Purity: >95%
• Buffer: Presentation State: Purified
• Stability: Stable for at least 3 months from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_000336
• Locus ID: 6622
• Cytogenetics: 4q22.1
• Synonyms: NACP; PARK1; PARK4; PD1
• Summary: 'Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]'
• Protein Families: Druggable Genome
• Protein Pathways: Alzheimer's disease, Parkinson's disease