Senataxin (SETX) Mutant (NM_015046) Human Recombinant Protein

CAT#: TP701002

Purified recombinant protein of Human senataxin (SETX), (L389S) mutant protein, esidues Met1-Phe500, expressed in HEK293 cells, 20ug

Product Images

Specifications

Product Data

• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence: A DNA sequence from TrueORF clone, RC222616, encoding the region (Met1-Phe500) of SETX(L389S)
• Tag: C-Myc/DDK
• Predicted MW: 57.8 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_055861
• Locus ID: 23064
• Cytogenetics: 9q34.13
• Refseq Size: 8583
• Refseq ORF: 8031
• Synonyms: ALS4; AOA2; bA479K20.2; SCAN2; SCAR1; Sen1
• Summary: This gene encodes a protein named for its homology to the Sen1p protein of fungi which has RNA helicase activity encoded by a domain at the C-terminal end of the protein. The protein encoded by this gene contains a DNA/RNA helicase domain at its C-terminal end which suggests that it may be involved in both DNA and RNA processing. Mutations in this gene have been associated with ataxia-ocular apraxia-2 (AOA2) and an autosomal dominant form of juvenile amyotrophic lateral sclerosis (ALS4). [provided by RefSeq, Jul 2008]