SH2B3 Mutant (R262W) Human Recombinant Protein

CAT#: TP701128

Purified mutant recombinant protein of Human SH2B adaptor protein 3 (SH2B3), mutation at(R262W)


USD 748.00

5 Days*

Size
    • 20 ug

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Specifications

Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence A DNA sequence from TrueORF clone, RC218359, encoding the full-length of SH2B3(R262W)
Tag Myc-DDK
Predicted MW 63 kDa
Concentration >50 ug/mL as determined by microplate Bradford method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Storage Store at -80°C after receiving vials.
Stability Stable for at least 12 months from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_005466.1
Locus ID 10019
Cytogenetics 12q24.12
Refseq Size 5423
Refseq ORF 1725
Synonyms IDDM20; LNK
Summary This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Protein Pathways Neurotrophin signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.