SH2B3 Mutant (R262W) Human Recombinant Protein

CAT#: TP701128

Purified mutant recombinant protein of Human SH2B adaptor protein 3 (SH2B3), mutation at（R262W)

Product Images

Purified recombinant protein SH2B3 (R262W) was analyzed by SDS-PAGE gel and Coomossie Blue Staining.

Specifications

Product Data

• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence: A DNA sequence from TrueORF clone, RC218359, encoding the full-length of SH2B3(R262W)
• Tag: Myc-DDK
• Predicted MW: 63 kDa
• Concentration: >50 ug/mL as determined by microplate Bradford method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
• Storage: Store at -80°C after receiving vials.
• Stability: Stable for at least 12 months from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_005466.1
• Locus ID: 10019
• Cytogenetics: 12q24.12
• Refseq Size: 5423
• Refseq ORF: 1725
• Synonyms: IDDM20; LNK
• Summary: This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
• Protein Pathways: Neurotrophin signaling pathway