NUMB1 Mutant (R262W) Human Recombinant Protein

CAT#: TP701136

Purified mutant recombinant protein of Human numb homolog (Drosophila) (NUMB), transcript variant 1,mutation at(R262W)


USD 748.00

5 Days*

Size
    • 20 ug

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Specifications

Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence A DNA sequence from TrueORF clone, RC220960, encoding the full-length of NUMB(S413A)
Tag Myc-DDK
Predicted MW 70.6 kDa
Concentration >50 ug/mL as determined by microplate Bradford method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Storage Store at -80°C after receiving vials.
Stability Stable for at least 12 months from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_001005743.1
Locus ID 8650
Cytogenetics 14q24.2-q24.3
Refseq Size 3647
Refseq ORF 1953
Synonyms C14orf41; c14_5527; S171
Summary The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Protein Pathways Notch signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.