ADAR Mutant (K744R) Human Recombinant Protein

CAT#: TP701139

Purified mutant recombinant protein of Human adenosine deaminase, RNA-specific (ADAR), transcript variant 4，mutation at（K744R)

Product Images

Purified recombinant protein ADAR (K744R) was analyzed by SDS-PAGE gel and Coomossie Blue Staining.

Specifications

Product Data

• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence: A DNA sequence from TrueORF clone, RC219761, encoding the full-length of ADAR(K744R)
• Tag: Myc-DDK
• Predicted MW: 103.5 kDa
• Concentration: >50 ug/mL as determined by microplate Bradford method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
• Storage: Store at -80°C after receiving vials.
• Stability: Stable for at least 12 months from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_001020278.1
• Locus ID: 103
• Cytogenetics: 1q21.3
• Refseq Size: 6532
• Refseq ORF: 2796
• Synonyms: ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1; IFI-4; IFI4; K88DSRBP; P136
• Summary: 'This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]'
• Protein Families: Druggable Genome
• Protein Pathways: Cytosolic DNA-sensing pathway