PCSK9 Mutant (NM_174936) Human Recombinant Protein
CAT#: TP721051
Purified recombinant protein of Human proprotein convertase subtilisin/kexin type 9 (PCSK9), D374Y mutant.
Product Images
Specifications
Product Data | |
Species | Human |
Expression Host | HEK293 |
Expression cDNA Clone or AA Sequence | QEDEDGDYEELVLALRSEEDGLAEAPEHGTTATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSyCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAVARCAPDEELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSVHTAPPAEASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGHREASIHASCCHAPGLECKVKEHGIPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRDVSTTGSTSEGAVTAVAICCRSRHLAQASQELQVDHHHHHH |
Tag | C-His |
Predicted MW | 84.78 kDa |
Concentration | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | Lyophilized from a 0.2 µM filtered solution of 50mM HEPES, 150mM NaCl, pH 7.4 |
Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg) |
Storage | Store at -80°C. |
Stability | Stable for at least 6 months from date of receipt under proper storage and handling conditions. |
Reference Data | |
RefSeq | NP_777596 |
Locus ID | 255738 |
Cytogenetics | 1p32.3 |
Refseq Size | 3636 |
Refseq ORF | 2076 |
Synonyms | FH3; HCHOLA3; LDLCQ1; NARC-1; NARC1; PC9 |
Summary | This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] |
Protein Families | Secreted Protein |
Documents
Resources
Recombinant Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC403563 | PCSK9 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 155.00 |
|
LY403563 | Transient overexpression lysate of proprotein convertase subtilisin/kexin type 9 (PCSK9) |
USD 495.00 |
|
PH320000 | PCSK9 MS Standard C13 and N15-labeled recombinant protein (NP_777596) |
USD 2,055.00 |
|
TP320000 | Recombinant protein of human proprotein convertase subtilisin/kexin type 9 (PCSK9) |
USD 867.00 |
|
TP700053 | Recombinant protein of secreted form of human proprotein convertase subtilisin/kexin type 9 (PCSK9) |
USD 748.00 |
|
TP720768 | Purified recombinant protein of Human proprotein convertase subtilisin/kexin type 9 (PCSK9) |
USD 300.00 |
|
TP723879 | Purified recombinant protein of Human proprotein convertase subtilisin/kexin type 9 (PCSK9) |
USD 270.00 |
{0} Product Review(s)
Be the first one to submit a review