Vitronectin Human Protein

CAT#: AR00154PU-N

Vitronectin human protein, 0.1 mg


USD 610.00

5 Days*

Size
    • 100 ug

Product Images

Specifications

Product Data
Species Human
Protein Source Plasma
Concentration lot specific
Purity >98% pure (SDS-PAGE). Column chromatography
Buffer Presentation State: Purified
State: Liquid purified Ig
Buffer System: 0.05M Sodium phosphate, pH 7.4 containing 0.1M Sodium chloride
Preparation Liquid purified Ig
Applications Second order rate constants for inhibition of:
uPA = 6.3 x 10e6 M-1s-1
tPA = 5.7 x 10e6 M-1s-1
Protein Description Human Vitronectin
Note Caution: Source material supplied to your facility has been tested for the detection of HIV antibody, Hepatitis B surface antigen, antibody to Hepatitis C, HIV 1 antigen(s), antibody to HTLV - I/II, and syphilis with FDA approved test kits. All units were found to be non-reactive/negative for these tests. Nevertheless, all products from human sources should be handled as potentially infectious.
Storage Store the antibody at -70°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Reference Data
RefSeq NP_000629
Locus ID 7448
Cytogenetics 17q11.2
Synonyms V75; VN; VNT
Summary 'The protein encoded by this gene functions in part as an adhesive glycoprotein. Differential expression of this protein can promote either cell adhesion or migration as it links cells to the extracellular matrix through a variety of ligands. These ligands include integrins, plasminogen activator inhibitor-1, and urokinase plasminogen activator receptor. This secreted protein can be present in the plasma as a monomer or dimer and forms a multimer in the extracellular matrix of several tissues. This protein also inhibits the membrane-damaging effect of the terminal cytolytic complement pathway and binds to several serpin serine protease inhibitors. This protein can also promote extracellular matrix degradation and thus plays a role in tumorigenesis. It is involved in a variety of other biological processes such as the regulation of the coagulation pathway, wound healing, and tissue remodeling. The heparin-binding domain of this protein give it anti-microbial properties. It is also a lipid binding protein that forms a principal component of high density lipoprotein. [provided by RefSeq, Aug 2020]'
Protein Families Druggable Genome, Secreted Protein
Protein Pathways ECM-receptor interaction, Focal adhesion

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.