Apolipoprotein H / Apo H Human Protein

CAT#: BA1044

Apolipoprotein H / Apo H human protein, 1 mg

Specifications

Product Data

• Species: Human
• Protein Source: Plasma
• Concentration: lot specific
• Purity: >95% >95 % pure (SDS-PAGE).
• Buffer: Presentation State: Purified
  State: Liquid protein purified by column chromatography.
  Buffer System: 20 mM HEPES-NaOH, 0.16 M Sodium Chloride, pH 7.5 with 0.1 mM PMSF, 20% glycerol, containing 0.1 % bromo-nitro-dioxane/methylisothiazoline as preservative.
• Preparation: Liquid protein purified by column chromatography.
• Applications: ELISA: 0.4-0.8 µg/well.
  After thawing, mix thoroughly by vortexing before use!
• Protein Description: Highy pure Beta 2 Glycoprotein I also known as Apolipoprotein H. Human IgA, IgG and IgM are not detectable by Western blot.
• Note: Caution: All human source materials have tested negative for HIV1, HIV2, HCV antibodies and HBsAg. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious.
• Storage: Store the antigen at -20 °C or -70 °C. Avoid multiple freeze/thaw cycles.
• Stability: Shelf life: six months from despatch.

Reference Data

• RefSeq: NP_000033
• Locus ID: 350
• Cytogenetics: 17q24.2
• Synonyms: B2G1; B2GP1; BG
• Summary: 'Apolipoprotein H, also known as beta-2-glycoprotein I, is a component of circulating plasma lipoproteins. It has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, hemostasis, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome (APS). The anti-beta (2) glycoprotein I antibodies from APS patients, mediate inhibition of activated protein C which has anticoagulant properties. Because beta-2-GPI is the main autoantigen in patients with APS, the disruption of this pathway by autoantibodies may be an important mechanism for thrombosis in patients with APS.[provided by RefSeq, Dec 2019]'
• Protein Families: Druggable Genome, Secreted Protein