Cathepsin D Human Protein

CAT#: BA115

Cathepsin D human protein, 25 µg

Specifications

Product Data

• Species: Human
• Protein Source: Liver
• Concentration: lot specific
• Purity: ≥95 pure by SDS-PAGE
• Buffer: Presentation State: Purified
  State: Lyophilized purified protein
  Buffer System: 2 mM Sodium Phosphate, pH 6.5
  Preservative: None
• Bioactivity: Specific: 396 Units/mg (prior to lyophilization).
  One unit is the amount of enzyme which digests hemoglobin releasing peptides which are soluble in 10% TCA. The reaction is measured by an increase of an A280 of 1.0 per 60 minutes at 37ºC.
  Substrate: Acid denatured hemoglobin (0.2% in reaction mixture).
  Buffer: 0.1 M formate, pH 3.3
• Reconstitution: Restore with 358 µl distilled water
• Preparation: Lyophilized purified protein
• Protein Description: Purified Human Cathepsin D
• Note: Caution: All human source materials have tested negative for HIV 1, HIV 2, anti-HCV, anti-HBc antibodies and HBsAg. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious.
• Storage: Store the product at -20°C.
  Avoid mulitiple freeze and thaw cycles.
• Stability: Shelf life: six months from despatch.

Reference Data

• RefSeq: NP_001900
• Locus ID: 1509
• Cytogenetics: 11p15.5
• Synonyms: CLN10; CPSD; HEL-S-130P
• Summary: 'This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015]'
• Protein Families: Druggable Genome, Protease
• Protein Pathways: Lysosome