Haptoglobin Human Protein

CAT#: BA311

Haptoglobin human protein, 5 mg

Specifications

Product Data

• Species: Human
• Protein Source: Plasma
• Concentration: lot specific
• Purity: >95% pure by SDS-PAGE
• Buffer: Presentation State: Purified
  State: Lyophilized purified protein
  Preservative: None
• Preparation: Lyophilized purified protein
• Protein Description: Human Plasma Haptoglobin.
  Polymorphic form (mixture of 1-1, 2-1, and/or 2-2).
• Note: Caution: All human source materials have tested negative for HIV 1, HIV 2, anti-HCV, anti-HBc antibodies and HBsAg. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious.
• Storage: Upon receipt, store at -20°C. Avoid repeated freezing and thawing.
• Stability: Shelf life: One year from despatch.

Reference Data

• RefSeq: NP_001119574
• Locus ID: 3240
• Cytogenetics: 16q22.2
• Synonyms: BP; HP2ALPHA2; HPA1S
• Summary: 'This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]'
• Protein Families: Druggable Genome, Protease, Secreted Protein, Transmembrane