KLKB1 / Kininogen Human Protein

CAT#: BA371

KLKB1 / Kininogen human protein, 50 µg

Specifications

Product Data

• Species: Human
• Protein Source: Plasma
• Concentration: lot specific
• Purity: >95% pure by SDS-PAGE.
• Buffer: Presentation State: Purified
  State: Lyophilized purified protein.
  Buffer System: 20mM Tris-HCl, pH 7.8 containing 100 mM Sodium Chloride without preservatives.
• Bioactivity: Specific: > / = 15 units per mg. One unit is defined as the amount of enzyme that will hydrolyze 1 µmole of D-Pro-Phe-Arg-pNA (Chromogenix S-2303) per minute at 25°C, pH 7.8.
• Reconstitution: Restore with 96.5 µl distilled water.
• Preparation: Lyophilized purified protein.
• Protein Description: Purified Human Plasma Kallikrein.
• Note: Caution: All human source materials have tested negative for HIV1, HIV2, HBc, HCV antibodies and HBsAg. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious.
• Storage: Store the antigen at -20 °C.
• Stability: Shelf life: six months from despatch.

Reference Data

• RefSeq: NP_000883
• Locus ID: 3818
• Cytogenetics: 4q35.2
• Synonyms: KLK3; PKK; PKKD; PPK
• Summary: 'This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]'
• Protein Families: Druggable Genome, Protease
• Protein Pathways: Complement and coagulation cascades