Alpha-2-macroglobulin / A2M Human Protein

CAT#: BA432

Alpha-2-macroglobulin / A2M human protein, 1 mg


USD 260.00

5 Days*

Size
    • 1 mg

Product Images

Specifications

Product Data
Species Human
Protein Source Plasma
Concentration lot specific
Purity >95% pure by SDS-PAGE.
Buffer Presentation State: Purified
State: Lyophilized purified protein.
Buffer System: 30mM Sodium Phosphate, pH 7.0 containing 1mg glycine and no preservative.
Reconstitution Restore with 340 µl distilled water.
Preparation Lyophilized purified protein.
Note Caution: All human source materials have tested negative for HIV 1, HIV 2, anti-HCV, anti-HBc antibodies and HBsAg. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious.
Storage Store at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Reference Data
RefSeq NP_000005
Locus ID 2
Cytogenetics 12p13.31
Synonyms A2MD; CPAMD5; FWP007; S863-7
Summary 'The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]'
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Complement and coagulation cascades

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.