Plasminogen / PLG Human Protein

CAT#: BA522

Plasminogen / PLG human protein, 1 mg

Specifications

Product Data

• Species: Human
• Protein Source: Plasma
• Concentration: lot specific
• Purity: >95% pure by SDS-PAGE
• Buffer: Presentation State: Purified
  State: Lyophilized purified fraction
  Buffer System: 20mM Tris, pH 7.5, containing 2mM EDTA
  Preservative: None
• Bioactivity: Specific: Activity : ≥ 120 units per mg protein.
  One unit is defined as the amount of enzyme, which will hydrolyze 1 µmole of N-tosyl-L-arginine ester in 30 minutes at 37°C at pH 8.0.
• Reconstitution: Restore with 0.412 ml distilled water.
• Preparation: Lyophilized purified fraction
• Protein Description: Human Plasminogen.
• Note: Caution: All human source materials have tested non-reactive for HBsAg, and for anti-HCV, anti HBc and negative for HIV 1, HIV 2 antibodies. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious.
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.

Reference Data

• RefSeq: NP_000292
• Locus ID: 5340
• Cytogenetics: 6q26
• Summary: 'The plasminogen protein encoded by this gene is a serine protease that circulates in blood plasma as an inactive zymogen and is converted to the active protease, plasmin, by several plasminogen activators such as tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), kallikrein, and factor XII (Hageman factor). The conversion of plasminogen to plasmin involves the cleavage of the peptide bond between Arg-561 and Val-562. Plasmin cleavage also releases the angiostatin protein which inhibits angiogenesis. Plasmin degrades many blood plasma proteins, including fibrin-containing blood clots. As a serine protease, plasmin cleaves many products in addition to fibrin such as fibronectin, thrombospondin, laminin, and von Willebrand factor. Plasmin is inactivated by proteins such as alpha-2-macroglobulin and alpha-2-antiplasmin in addition to inhibitors of the various plasminogen activators. Plasminogen also interacts with plasminogen receptors which results in the retention of plasmin on cell surfaces and in plasmin-induced cell signaling. The localization of plasminogen on cell surfaces plays a role in the degradation of extracellular matrices, cell migration, inflamation, wound healing, oncogenesis, metastasis, myogenesis, muscle regeneration, neurite outgrowth, and fibrinolysis. This protein may also play a role in acute respiratory distress syndrome (ARDS) which, in part, is caused by enhanced clot formation and the suppression of fibrinolysis. Compared to other mammals, the cluster of plasminogen-like genes to which this gene belongs has been rearranged in catarrhine primates. [provided by RefSeq, May 2020]'
• Protein Families: Druggable Genome, Protease, Secreted Protein
• Protein Pathways: Complement and coagulation cascades, Neuroactive ligand-receptor interaction