Kallikrein-3 / PSA / KLK3 Human Protein

CAT#: BA539

Kallikrein-3 / PSA / KLK3 human protein, 0.1 mg


USD 485.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Species Human
Protein Source Seminal Fluid
Concentration lot specific
Purity >96% pure by SDS-PAGE
Buffer State: Liquid (sterile filtered) purified protein.
Buffer System: PBS, pH 7.5 containing 0.09% Sodium Azide as preservative.
Preparation Liquid (sterile filtered) purified protein.
Applications ELISA.
Western Blot.
Protein Description Prostate Specific Antigen (PSA) is a glycoprotein of approximately 30 kDa found mainly in prostatic tissue and seminal fluid. PSA is also present in small quantities in the serum of normal men and is often elevated in the presence of prostate cancer and in other prostate disorders.
Note Caution: Tested and found negative for HBsAg and HIV-1 and 2, and HCV antibodies by FDA approved method, but according to laboratory practice should still be handled as though infectious.
Storage Store undiluted at 2-8°C for one month or (in alqiuots) at -20°C for longer.
Avoid repeated freezing and thawing
Stability Shelf life: one year from despatch.
Reference Data
RefSeq NP_001025218
Locus ID 354
Cytogenetics 19q13.33
Synonyms APS; hK3; KLK2A1; PSA
Summary 'Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a protease which is synthesized in the epithelial cells of the prostate gland, and is present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. The serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Dec 2019]'
Protein Families Druggable Genome, Protease, Secreted Protein
Protein Pathways Pathways in cancer, Prostate cancer

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