Collagen type II alpha 1 chain (Adult Knee Cartilage) Human Protein

CAT#: RA003

Collagen type II alpha 1 chain (Adult Knee Cartilage) human protein, 0.1 mg

Specifications

Product Data

• Species: Human
• Protein Source: Cartilage
• Concentration: lot specific
• Purity: >98% Chromatographically and immunologically pure.
• Buffer: State: Liquid (sterile filtered) purified Ig fraction.
  Buffer System: 0.5M Acetic Acid containing 0.01% Sodium Azide as preservative.
• Preparation: Liquid (sterile filtered) purified Ig fraction.
• Applications: Suitable for use as a control or standard in indirect trapping ELISA for quantitation of antigen in serum using a standard curve, for Immunoprecipitation and for Western blotting
• Protein Description: This protein has been prepared from adult human knee cartilage and is free from other collagens, human serum proteins and non-collagen extracellular matrix proteins. This product reacts with anti-Collagen Type II. Reaction with anti-Collagen I, III, IV, V or VI is negligible (typically less than 1% cross reactivity was detected by ELISA).
• Storage: Store vial at 2-8°C prior to opening.
  This product is stable 2-8°C as an undiluted liquid.
  Dilute only prior to immediate use.
• Stability: Shelf life: one year from despatch.

Reference Data

• RefSeq: NP_001835
• Locus ID: 1280
• Cytogenetics: 12q13.11
• Synonyms: ANFH; AOM; COL11A3; SEDC; STL1
• Summary: 'This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. [provided by RefSeq, Jul 2008]'
• Protein Pathways: ECM-receptor interaction, Focal adhesion