Collagen type IV Bovine Protein

CAT#: RA008

Collagen type IV bovine protein, 0.5 mg

Specifications

Product Data

• Species: Bovine
• Protein Source: Placenta
• Concentration: lot specific
• Purity: >98% pure (chromatographically and immunologically pure).
• Buffer: State: Liquid (sterile filtered) purified Ig fraction.
  Buffer System: 0.5 M Sodium Acetate, pH 4.5 containing 0,01% Sodium Azide as preservative
• Preparation: Liquid (sterile filtered) purified Ig fraction.
• Applications: Suitable for use as a Control or Standard in indirect trapping ELISA for quantitation of antigen in serum using a standard curve, for Immunoprecipitation and for Western blotting
• Protein Description: This product has been prepared from Bovine Placenta and reacts with anti-Collagen Type IV. Reaction with anti-Collagen I, II, III, V or VI is negligible (typically less than 1% cross reactivity was detected by ELISA).
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: 6 month from despatch.

Reference Data

• RefSeq: NP_001290039
• Locus ID: 1282
• Cytogenetics: 13q34
• Synonyms: BSVD; BSVD1; RATOR
• Summary: 'This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]'
• Protein Pathways: ECM-receptor interaction, Focal adhesion, Pathways in cancer, Small cell lung cancer