Alpha-2-macroglobulin / A2M Human Protein
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Other products for "A2M"
Specifications
Product Data | |
Species | Human |
Concentration | lot specific |
Purity | >96% by SDS PAGE |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: TRIS buffered saline containing 0.1M Sucrose |
Preparation | Liquid purified protein |
Applications | ELISA. |
Protein Description | Purified alpha-2-macroglobulin from human serum. |
Note | Caution: (A full Health and Safety assessment is available upon request) Donor serum tested and found negative for HIV I and II antibodies, HBsAg and HCV antibodies. |
Storage | Store the protein at -20°C. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_000005 |
Locus ID | 2 |
Cytogenetics | 12p13.31 |
Synonyms | A2MD; CPAMD5; FWP007; S863-7 |
Summary | 'The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]' |
Protein Families | Druggable Genome, Secreted Protein |
Protein Pathways | Complement and coagulation cascades |
Documents
FAQs |
Resources
Recombinant Protein Resources |
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in shipping.