Alpha-2-macroglobulin / A2M Human Protein

CAT#: AR05066PU-N

Alpha-2-macroglobulin / A2M human protein, 1 mg

Specifications

Product Data

• Species: Human
• Concentration: lot specific
• Purity: >96% by SDS PAGE
• Buffer: Presentation State: Purified
  State: Liquid purified protein
  Buffer System: TRIS buffered saline containing 0.1M Sucrose
• Preparation: Liquid purified protein
• Applications: ELISA.
• Protein Description: Purified alpha-2-macroglobulin from human serum.
• Note: Caution: (A full Health and Safety assessment is available upon request) Donor serum tested and found negative for HIV I and II antibodies, HBsAg and HCV antibodies.
• Storage: Store the protein at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.

Reference Data

• RefSeq: NP_000005
• Locus ID: 2
• Cytogenetics: 12p13.31
• Synonyms: A2MD; CPAMD5; FWP007; S863-7
• Summary: 'The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]'
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Complement and coagulation cascades