Interleukin-1 beta / IL-1B Chicken Protein

CAT#: AR05233PU-S

Interleukin-1 beta / IL-1B chicken recombinant protein, 50 µg

Specifications

Product Data

• Species: Chicken
• Concentration: lot specific
• Purity: >85% by Ni chelate Chromatography
• Buffer: State: Liquid purified protein
  Buffer System: Phosphate buffered saline
• Preparation: Liquid purified protein
• Applications: In vitro Assay.
  Functional Assays.
• Protein Description: His-tagged recombinant chicken interleukin-1 beta expressed in E.coli. This antigen induces corticosterone secretion in vivo(1) and is the immunogen used to produce chicken IL-1beta antibody product code SP2127A.
• Storage: Store the protein at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: 3 month from despatch.

Reference Data

• RefSeq: NP_000567
• Locus ID: 3553
• UniProt ID: P01584
• Cytogenetics: 2q14.1
• Synonyms: IL-1; IL1-BETA; IL1beta; IL1F2
• Summary: 'The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2020]'
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Alzheimer's disease, Apoptosis, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Graft-versus-host disease, Hematopoietic cell lineage, MAPK signaling pathway, NOD-like receptor signaling pathway, Prion diseases, Toll-like receptor signaling pathway, Type I diabetes mellitus