HSPB1 / HSP27 Human Protein

CAT#: SA6031X

HSPB1 / HSP27 human recombinant protein, 0.5 mg

Product Images

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  MTERRVPFSL LRGPSWDPFR DWYPHSRLFD QAFGLPRLPE EWSQWLGGSS WPGYVRPLPP AAIESPAVAA PAYSRALSRQ LSSGVSEIRH TADRWRVSLD VNHFAPDELT VKTKDGVVEI TGKHEERQDE HGYISRCFTR KYTLPPGVDP TQVSSSLSPE GTLTVEAPMP KLATQSNEIT IPVTFESRAQ LGGPEAAKSD ETAAK
• Predicted MW: 22.7 kDa
• Concentration: lot specific
• Purity: >95% pure by SDS-PAGE
• Buffer: Presentation State: Purified
  State: Liquid purified protein
  Buffer System: 20 mM Hepes (pH 7.5) containing 1 mM DTT, 100 mM KCl
• Endotoxin: < 1.0 EU per 1µg of protein (determined by LAL method)
• Preparation: Liquid purified protein
• Protein Description: Recombinant Human Hsp27 was overexpressed in E. coli and purified by conventional chromatography.
• Storage: Store the antigen at 2-8°C for 1-2 weeks or (in aliquots) at -20°C to -70°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.

Reference Data

• RefSeq: NP_001531
• Locus ID: 3315
• UniProt ID: P04792, V9HW43
• Cytogenetics: 7q11.23
• Synonyms: CMT2F; HEL-S-102; HMN2B; HS.76067; Hsp25; HSP27; HSP28; SRP27
• Summary: 'This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]'
• Protein Pathways: MAPK signaling pathway, VEGF signaling pathway