Dopamine beta Hydroxylase (DBH) (NM_000787) Human Recombinant Protein
CAT#: TP312355
Recombinant protein of human dopamine beta-hydroxylase (dopamine beta-monooxygenase) (DBH)
Special Offer: Get a 20% discount on this product. Use code: "MVPro20".
Specifications
Product Data | |
Species | Human |
Expression Host | HEK293T |
Expression cDNA Clone or AA Sequence |
Recombinant protein was produced with TrueORF clone, RC212355. Click on the TrueORF clone link to view cDNA and protein sequences.
|
Tag | C-Myc/DDK |
Predicted MW | 64.9 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol |
Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_000778 |
Locus ID | 1621 |
UniProt ID | P09172 |
Cytogenetics | 9q34.2 |
Refseq Size | 2812 |
Refseq ORF | 1851 |
Synonyms | DBM; ORTHYP1 |
Summary | 'The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders. [provided by RefSeq, Aug 2017]' |
Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
Protein Pathways | Metabolic pathways, Tyrosine metabolism |
Documents
FAQs |
SDS |
Resources
Recombinant Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC424519 | DBH HEK293T cell transient overexpression lysate (as WB positive control) |
USD 187.00 |
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LY424519 | Transient overexpression lysate of dopamine beta-hydroxylase (dopamine beta-monooxygenase) (DBH) |
USD 605.00 |
|
PH312355 | DBH MS Standard C13 and N15-labeled recombinant protein (NP_000778) |
USD 2,055.00 |
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