TNNT3 (NM_001042780) Human Recombinant Protein
CAT#: TP312563
Recombinant protein of human troponin T type 3 (skeletal, fast) (TNNT3), transcript variant 3
View other "TNNT3" proteins (13)
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Specifications
Product Data | |
Species | Human |
Expression Host | HEK293T |
Expression cDNA Clone or AA Sequence |
>RC212563 representing NM_001042780
Red=Cloning site Green=Tags(s) MSDEEVEQVEEQYEEEEEAQEEEEVQEEEKPRPKLTAPKIPEGEKVDFDDIQKKRQNKDLMELQALIDSH FEARKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQNRLAEEKARREEEDAKRRAEDDLKKKKALS SMGANYSSYLAKADQKRGKKQTAREMKKKILAERRKPLNIDHLGEDKLRDKAKELWETLHQLEIDKFEFG EKLKRQKYDIMNVRARVQMLAKFSKKAGTPAKGKVGGRWK TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Tag | C-Myc/DDK |
Predicted MW | 29.6 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol |
Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Note | For culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_001036245 |
Locus ID | 7140 |
UniProt ID | P45378 |
Cytogenetics | 11p15.5 |
Refseq Size | 1193 |
Refseq ORF | 750 |
Synonyms | beta-TnTF; DA2B2; TNTF |
Summary | The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009] |
Documents
FAQs |
SDS |
Resources
Recombinant Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC402019 | TNNT3 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LC420809 | TNNT3 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LC420811 | TNNT3 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LC425799 | TNNT3 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LY402019 | Transient overexpression lysate of troponin T type 3 (skeletal, fast) (TNNT3), transcript variant 1 |
USD 396.00 |
|
LY420809 | Transient overexpression lysate of troponin T type 3 (skeletal, fast) (TNNT3), transcript variant 3 |
USD 396.00 |
|
LY420811 | Transient overexpression lysate of troponin T type 3 (skeletal, fast) (TNNT3), transcript variant 4 |
USD 396.00 |
|
LY425799 | Transient overexpression lysate of troponin T type 3 (skeletal, fast) (TNNT3), transcript variant 3 |
USD 396.00 |
|
PH312563 | TNNT3 MS Standard C13 and N15-labeled recombinant protein (NP_001036245) |
USD 2,055.00 |
|
PH316642 | TNNT3 MS Standard C13 and N15-labeled recombinant protein (NP_006748) |
USD 2,055.00 |
|
PH323893 | TNNT3 MS Standard C13 and N15-labeled recombinant protein (NP_001036247) |
USD 2,055.00 |
|
TP316642 | Recombinant protein of human troponin T type 3 (skeletal, fast) (TNNT3), transcript variant 1 |
USD 748.00 |
|
TP323893 | Recombinant protein of human troponin T type 3 (skeletal, fast) (TNNT3), transcript variant 4 |
USD 748.00 |
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