TAPA1 (CD81) (NM_004356) Human Recombinant Protein

CAT#: TP317508

Recombinant protein of human CD81 molecule (CD81)

Product Images

Plasma neuronal-derived exosome levels of CD81, measured by ELISA using recombinant CD81 (OriGene TP317508) as the standard, were not statistically different among cognitively normal controls (CNC), mild cognitive impairment (MCI), MCI converting to AD (ADC), and Alzheimer's disease patients (AD). Figure cited from Alzheimers Dement (Amst), PMID: 27408937

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  Coomassie blue staining of purified CD81 protein (Cat# TP317508). The protein was produced from HEK293T cells transfected with CD81 cDNA clone (Cat# RC217508) using MegaTran 2.0 (Cat# TT210002).

Specifications

Product Data

• Species: Human
• Expression Host: HEK293T
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Recombinant protein was produced with TrueORF clone, RC217508. Click on the TrueORF clone link to view cDNA and protein sequences.
• Tag: C-Myc/DDK
• Predicted MW: 25.6 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
• Bioactivity: ELISA standard (PMID: 27408937)
  ELISA standard (PMID: 27511944)
  ELISA standard (PMID: 27601437)
  ELISA standard (PMID: 28105773)
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_004347
• Locus ID: 975
• UniProt ID: P60033, A0A024RCB7
• Cytogenetics: 11p15.5
• Refseq Size: 1497
• Refseq ORF: 708
• Synonyms: CVID6; S5.7; TAPA1; TSPAN28
• Summary: 'The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]'
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: B cell receptor signaling pathway