Glucokinase (GCK) (NM_033508) Human Recombinant Protein
CAT#: TP318920
Recombinant protein of human glucokinase (hexokinase 4) (GCK), transcript variant 3
View other "GCK" proteins (13)
Special Offer: Get a 20% discount on this product. Use code: "MVPro20".
Specifications
Product Data | |
Species | Human |
Expression Host | HEK293T |
Expression cDNA Clone or AA Sequence |
Recombinant protein was produced with TrueORF clone, RC218920. Click on the TrueORF clone link to view cDNA and protein sequences.
|
Tag | C-Myc/DDK |
Predicted MW | 51.9 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol |
Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_277043 |
Locus ID | 2645 |
UniProt ID | P35557 |
Cytogenetics | 7p13 |
Refseq Size | 2566 |
Refseq ORF | 1392 |
Synonyms | FGQTL3; GK; GLK; HHF3; HK4; HKIV; HXKP; LGLK; MODY2 |
Summary | 'This gene encodes a member of the hexokinase family of proteins. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. The use of multiple promoters and alternative splicing of this gene result in distinct protein isoforms that exhibit tissue-specific expression in the pancreas and liver. In the pancreas, this enzyme plays a role in glucose-stimulated insulin secretion, while in the liver, this enzyme is important in glucose uptake and conversion to glycogen. Mutations in this gene that alter enzyme activity have been associated with multiple types of diabetes and hyperinsulinemic hypoglycemia. [provided by RefSeq, Aug 2017]' |
Protein Families | Druggable Genome |
Protein Pathways | Amino sugar and nucleotide sugar metabolism, Galactose metabolism, Glycolysis / Gluconeogenesis, Insulin signaling pathway, Maturity onset diabetes of the young, Metabolic pathways, Starch and sucrose metabolism, Type II diabetes mellitus |
Documents
FAQs |
SDS |
Resources
Recombinant Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC400059 | GCK HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LC403250 | GCK HEK293T cell transient overexpression lysate (as WB positive control) |
USD 187.00 |
|
LC409539 | GCK HEK293T cell transient overexpression lysate (as WB positive control) |
USD 187.00 |
|
LC429881 | GCK HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LY400059 | Transient overexpression lysate of glucokinase (hexokinase 4) (GCK), transcript variant 1 |
USD 396.00 |
|
LY403250 | Transient overexpression lysate of glucokinase (hexokinase 4) (GCK), transcript variant 3 |
USD 605.00 |
|
LY409539 | Transient overexpression lysate of glucokinase (hexokinase 4) (GCK), transcript variant 2 |
USD 605.00 |
|
LY429881 | Transient overexpression lysate of glucokinase (hexokinase 4) (GCK), transcript variant 2 |
USD 396.00 |
|
PH300472 | GCK MS Standard C13 and N15-labeled recombinant protein (NP_000153) |
USD 2,055.00 |
|
PH318920 | GCK MS Standard C13 and N15-labeled recombinant protein (NP_277043) |
USD 2,055.00 |
|
PH322793 | GCK MS Standard C13 and N15-labeled recombinant protein (NP_277042) |
USD 2,055.00 |
|
TP300472 | Recombinant protein of human glucokinase (hexokinase 4) (GCK), transcript variant 1 |
USD 867.00 |
|
TP322793 | Recombinant protein of human glucokinase (hexokinase 4) (GCK), transcript variant 2 |
USD 748.00 |
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