bcl 6 (BCL6) (NM_001706) Human Recombinant Protein

CAT#: TP319007

Recombinant protein of human B-cell CLL/lymphoma 6 (BCL6), transcript variant 1

Product Images

Coomassie blue staining of purified BCL6 protein (Cat# TP319007). The protein was produced from HEK293T cells transfected with BCL6 cDNA clone (Cat# RC219007) using MegaTran 2.0 (Cat# TT210002).

Specifications

Product Data

• Species: Human
• Expression Host: HEK293T
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Recombinant protein was produced with TrueORF clone, RC219007. Click on the TrueORF clone link to view cDNA and protein sequences.
• Tag: C-Myc/DDK
• Predicted MW: 78.7 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_001697
• Locus ID: 604
• UniProt ID: P41182
• Cytogenetics: 3q27.3
• Refseq Size: 3537
• Refseq ORF: 2118
• Synonyms: BCL5; BCL6A; LAZ3; ZBTB27; ZNF51
• Summary: 'The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]'
• Protein Families: Druggable Genome, Transcription Factors