UPF3B (NM_023010) Human Recombinant Protein
CAT#: TP321828
Recombinant protein of human UPF3 regulator of nonsense transcripts homolog B (yeast) (UPF3B), transcript variant 2
View other "UPF3B" proteins (5)
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Specifications
Product Data | |
Species | Human |
Expression Host | HEK293T |
Expression cDNA Clone or AA Sequence |
Recombinant protein was produced with TrueORF clone, RC221828. Click on the TrueORF clone link to view cDNA and protein sequences.
|
Tag | C-Myc/DDK |
Predicted MW | 56 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol |
Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_075386 |
Locus ID | 65109 |
UniProt ID | Q9BZI7 |
Cytogenetics | Xq24 |
Refseq Size | 2365 |
Refseq ORF | 1410 |
Synonyms | HUPF3B; MRX62; MRXS14; RENT3B; UPF3BP1; UPF3BP2; UPF3BP3; Upf3p-X; UPF3X |
Summary | This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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Resources
Recombinant Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC409114 | UPF3B HEK293T cell transient overexpression lysate (as WB positive control) |
USD 187.00 |
|
LC411484 | UPF3B HEK293T cell transient overexpression lysate (as WB positive control) |
USD 187.00 |
|
LY409114 | Transient overexpression lysate of UPF3 regulator of nonsense transcripts homolog B (yeast) (UPF3B), transcript variant 1 |
USD 605.00 |
|
LY411484 | Transient overexpression lysate of UPF3 regulator of nonsense transcripts homolog B (yeast) (UPF3B), transcript variant 2 |
USD 605.00 |
|
PH321828 | UPF3B MS Standard C13 and N15-labeled recombinant protein (NP_075386) |
USD 2,055.00 |
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