AIF (AIFM1) (NM_004208) Human Recombinant Protein
CAT#: TP324064
Recombinant protein of human apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1), nuclear gene encoding mitochondrial protein, transcript variant 1
View other "AIFM1" proteins (8)
Special Offer: Get a 20% discount on this product. Use code: "MVPro20".
Specifications
Product Data | |
Species | Human |
Expression Host | HEK293T |
Expression cDNA Clone or AA Sequence |
Recombinant protein was produced with TrueORF clone, RC224064. Click on the TrueORF clone link to view cDNA and protein sequences.
|
Tag | C-Myc/DDK |
Predicted MW | 66.7 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol |
Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_004199 |
Locus ID | 9131 |
UniProt ID | O95831 |
Cytogenetics | Xq26.1 |
Refseq Size | 2215 |
Refseq ORF | 1839 |
Synonyms | AIF; CMT2D; CMTX4; COWCK; COXPD6; DFNX5; NADMR; NAMSD; PDCD8 |
Summary | This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and cognitive disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, Aug 2015] |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Apoptosis |
Documents
FAQs |
SDS |
Resources
Recombinant Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC407552 | AIFM1 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LC418136 | AIFM1 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 187.00 |
|
LY407552 | Transient overexpression lysate of apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1), nuclear gene encoding mitochondrial protein, transcript variant 2 |
USD 396.00 |
|
LY418136 | Transient overexpression lysate of apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1), nuclear gene encoding mitochondrial protein, transcript variant 1 |
USD 605.00 |
|
PH310668 | AIFM1 MS Standard C13 and N15-labeled recombinant protein (NP_665811) |
USD 2,055.00 |
|
PH324064 | AIFM1 MS Standard C13 and N15-labeled recombinant protein (NP_004199) |
USD 2,055.00 |
|
TP310668 | Recombinant protein of human apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1), nuclear gene encoding mitochondrial protein, transcript variant 2 |
USD 867.00 |
|
TP720244 | Recombinant protein of human apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1), transcript variant 4 |
USD 330.00 |
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