NEIL2 (NM_001135746) Human Recombinant Protein
CAT#: TP327701
Recombinant protein of human nei like 2 (E. coli) (NEIL2), transcript variant 2
View other "NEIL2" proteins (9)
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Specifications
Product Data | |
Species | Human |
Expression Host | HEK293T |
Expression cDNA Clone or AA Sequence |
Recombinant protein was produced with TrueORF clone, RC227701. Click on the TrueORF clone link to view cDNA and protein sequences.
|
Tag | C-Myc/DDK |
Predicted MW | 36.6 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol |
Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_001129218 |
Locus ID | 252969 |
UniProt ID | Q969S2, A0A024R361 |
Cytogenetics | 8p23.1 |
Refseq Size | 2202 |
Refseq ORF | 996 |
Synonyms | NEH2; NEI2 |
Summary | This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017] |
Protein Families | Druggable Genome |
Protein Pathways | Base excision repair |
Documents
FAQs |
SDS |
Resources
Recombinant Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC408061 | NEIL2 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LC427692 | NEIL2 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LC427694 | NEIL2 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LY408061 | Transient overexpression lysate of nei like 2 (E. coli) (NEIL2), transcript variant 1 |
USD 396.00 |
|
LY427692 | Transient overexpression lysate of nei like 2 (E. coli) (NEIL2), transcript variant 2 |
USD 396.00 |
|
LY427694 | Transient overexpression lysate of nei like 2 (E. coli) (NEIL2), transcript variant 4 |
USD 396.00 |
|
PH300913 | NEIL2 MS Standard C13 and N15-labeled recombinant protein (NP_659480) |
USD 2,055.00 |
|
PH327701 | NEIL2 MS Standard C13 and N15-labeled recombinant protein (NP_001129218) |
USD 2,055.00 |
|
TP300913 | Recombinant protein of human nei like 2 (E. coli) (NEIL2), transcript variant 1 |
USD 823.00 |
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