Elob (NM_026305) Mouse Recombinant Protein

CAT#: TP500551

Purified recombinant protein of Mouse elongin B (Elob), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Specifications

Product Data

• Species: Mouse
• Expression Host: HEK293T
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence from Mouse cDNA ORF Clone, MR200551, encoding Mouse full-length Elob.
• Tag: C-MYC/DDK
• Predicted MW: 13.6 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Storage: Store at -80°C after receiving vials.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_080581
• Locus ID: 67673
• UniProt ID: P62869
• Cytogenetics: 17 A3.3
• Refseq Size: 508
• Refseq ORF: 357
• Synonyms: 0610040H15Rik; Tceb2
• Summary: The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes. [UniProtKB/Swiss-Prot Function]