FLT3 (NM_004119) Human Recombinant Protein

CAT#: TP700113

Recombinant protein of human fms-related tyrosine kinase 3 (FLT3), with C-terminal DDK/His tag, expressed in human cells, 20 µg


  View other "FLT3" proteins (5)

USD 748.00

In Stock*

Size
    • 20 ug

Product Images

Other products for "FLT3"

Specifications

Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
A DNA sequence from TrueORF clone, RC600013, encoding the region (Asn27 – Ser543) of human FLT3
Tag C-DDK/His
Predicted MW 61.1 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer PBS, pH7.4, 10% glycerol
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_004110
Locus ID 2322
UniProt ID P36888
Cytogenetics 13q12.2
Refseq Size 3848
Refseq ORF 1629
Synonyms CD135; FLK-2; FLK2; STK1
Summary 'This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]'
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane
Protein Pathways Acute myeloid leukemia, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Pathways in cancer

Documents

Other Versions

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.