Bone Sialoprotein (IBSP) (NM_004967) Human Recombinant Protein

CAT#: TP700289

Purified recombinant protein of human integrin-binding sialoprotein (IBSP), with C-terminal DDK/His tag, expressed in human cells;


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USD 748.00

2 Weeks*

Size
    • 20 ug

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Specifications

Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
A DNA sequence from TrueORF clone, RC222901, encoding the region (Phe17 – Gln317) of human IBSP
Tag C-DDK/6xHis
Predicted MW 35.5 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer PBS, pH7.4, 10% glycerol
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_004958
Locus ID 3381
UniProt ID P21815
Cytogenetics 4q22.1
Refseq Size 1108
Refseq ORF 951
Synonyms BNSP; BSP; BSP-II; SP-II
Summary The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways ECM-receptor interaction, Focal adhesion

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.