Apolipoprotein H (APOH) (NM_000042) Human Recombinant Protein

CAT#: TP701230

Purified recombinant protein of Human apolipoprotein H (beta-2-glycoprotein I) (APOH) domain 1, Gly20-Cys84, with C-terminal His tag, expressed in HEK293 cells, 50ug

Product Images

Purified recombinant protein APOH was analyzed by SDS-PAGE gel and Coomossie Blue Staining.

Specifications

Product Data

• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence from TrueORF clone, RC205017, encoding the region(Gly20-Cys84) of APOH
• Tag: C-His
• Predicted MW: 8.2 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: PBS, pH7.4, 10% glycerol
• Storage: Store at -80°C after receiving vials.
• Stability: Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_000033
• Locus ID: 350
• UniProt ID: P02749, A0A384NKM6
• Cytogenetics: 17q24.2
• Refseq Size: 1216
• Refseq ORF: 1035
• Synonyms: B2G1; B2GP1; BG
• Summary: 'Apolipoprotein H, also known as beta-2-glycoprotein I, is a component of circulating plasma lipoproteins. It has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, hemostasis, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome (APS). The anti-beta (2) glycoprotein I antibodies from APS patients, mediate inhibition of activated protein C which has anticoagulant properties. Because beta-2-GPI is the main autoantigen in patients with APS, the disruption of this pathway by autoantibodies may be an important mechanism for thrombosis in patients with APS.[provided by RefSeq, Dec 2019]'
• Protein Families: Druggable Genome, Secreted Protein