Apolipoprotein H (APOH) (NM_000042) Human Recombinant Protein

CAT#: TP701230

Purified recombinant protein of Human apolipoprotein H (beta-2-glycoprotein I) (APOH) domain 1, Gly20-Cys84, with C-terminal His tag, expressed in HEK293 cells, 50ug


USD 823.00

2 Weeks*

Size
    • 50 ug

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Specifications

Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
A DNA sequence from TrueORF clone, RC205017, encoding the region(Gly20-Cys84) of APOH
Tag C-His
Predicted MW 8.2 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer PBS, pH7.4, 10% glycerol
Storage Store at -80°C after receiving vials.
Stability Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_000033
Locus ID 350
UniProt ID P02749, A0A384NKM6
Cytogenetics 17q24.2
Refseq Size 1216
Refseq ORF 1035
Synonyms B2G1; B2GP1; BG
Summary 'Apolipoprotein H, also known as beta-2-glycoprotein I, is a component of circulating plasma lipoproteins. It has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, hemostasis, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome (APS). The anti-beta (2) glycoprotein I antibodies from APS patients, mediate inhibition of activated protein C which has anticoagulant properties. Because beta-2-GPI is the main autoantigen in patients with APS, the disruption of this pathway by autoantibodies may be an important mechanism for thrombosis in patients with APS.[provided by RefSeq, Dec 2019]'
Protein Families Druggable Genome, Secreted Protein

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.