DCK (NM_000788) Human Recombinant Protein

CAT#: TP710018

Recombinant protein of human deoxycytidine kinase (DCK), full length with N-terminal polyhistidine tag, expressed in sf9 cells.

Product Images

Specifications

Product Data

• Species: Human
• Expression Host: Sf9
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence from TrueORF clone, RC210767, encoding human full-length DCK
• Tag: N-His
• Predicted MW: 30 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 50mM Tris-HCl pH8.0, 150mM NaCl, 20% glycerol
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_000779
• Locus ID: 1633
• UniProt ID: P27707, F5CTF3
• Cytogenetics: 4q13.3
• Refseq Size: 2618
• Refseq ORF: 780
• Summary: ' Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]'
• Protein Families: Druggable Genome
• Protein Pathways: Purine metabolism, Pyrimidine metabolism