PR3 (PRTN3) (NM_002777) Human Recombinant Protein
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Specifications
Product Data | |
Species | Human |
Expression Host | HEK293 |
Expression cDNA Clone or AA Sequence |
Ala26-Arg249
|
Tag | C-His |
Predicted MW | 25.6 kDa |
Concentration | lot specific |
Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | Supplied as a 0.2 um filtered solution of 10mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.0. |
Endotoxin | < 0.1 EU per µg protein as determined by LAL test |
Storage | Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles. |
Stability | Stable for at least 3 months from date of receipt under proper storage and handling conditions. |
Reference Data | |
RefSeq | NP_002768 |
Locus ID | 5657 |
UniProt ID | P24158 |
Cytogenetics | 19p13.3 |
Synonyms | ACPA; AGP7; C-ANCA; CANCA; MBN; MBT; NP-4; NP4; P29; PR-3; PR3 |
Summary | Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279).[UniProtKB/Swiss-Prot Function] |
Protein Families | Druggable Genome, Protease |
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