uPA (PLAU) (NM_002658) Human Recombinant Protein

CAT#: TP720654

Purified recombinant protein of Human plasminogen activator, urokinase (PLAU), transcript variant 1


  View other "uPA" proteins (4)

USD 330.00

3 Weeks*

Size
    • 10 ug

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Frequently bought together (1)
PLAU mouse monoclonal antibody, clone OTI5H4 (formerly 5H4)
    • 100 ul

USD 379.00

Specifications

Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Tag C-His
Predicted MW 47.41 kDa
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Supplied as a 0.2 um filtered solution of 20mM HEPES, 2mM CaCl2, 10% Glycerol, pH 7.4.
Endotoxin Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
Storage Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Stability Stable for at least 3 months from date of receipt under proper storage and handling conditions.
Reference Data
RefSeq NP_002649
Locus ID 5328
UniProt ID P00749, Q59GZ8, A0A024QZM9
Cytogenetics 10q22.2
Refseq Size 2395
Refseq ORF 1293
Synonyms ATF; BDPLT5; QPD; u-PA; UPA; URK
Summary This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Protease
Protein Pathways Complement and coagulation cascades

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.