CFHL1 (CFHR1) (NM_002113) Human Recombinant Protein

CAT#: TP720693

Purified recombinant protein of Human complement factor H-related 1 (CFHR1)

Specifications

Product Data

• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Glu19-Arg330
• Tag: C-6His
• Predicted MW: 36.78 kDa
• Concentration: lot specific
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, 0.01%Tween 80, pH 7.4
• Endotoxin: Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
• Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
• Stability: Stable for at least 6 months from date of receipt under proper storage and handling conditions.

Reference Data

• RefSeq: NP_002104
• Locus ID: 3078
• UniProt ID: Q03591
• Cytogenetics: 1q31.3
• Refseq Size: 1312
• Refseq ORF: 990
• Synonyms: CFHL; CFHL1; CFHL1P; CFHR1P; FHR-1; FHR1; H36; H36-1; H36-2; HFL1; HFL2
• Summary: This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009]
• Protein Families: Secreted Protein