UBE2C (NM_181801) Human Recombinant Protein

CAT#: TP720898XL

Purified recombinant protein of Human ubiquitin-conjugating enzyme E2C (UBE2C), transcript variant 4

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Ile141-Ser188
• Tag: N-Trx&His
• Predicted MW: 23.3 kDa
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: Lyophilized from a 0.2 μm filtered solution of 50mMTris,150mMNaCl,1mMEDTA,pH8.0.
• Storage: Store at -80°C.
• Stability: Stable for at least 3 months from date of receipt under proper storage and handling conditions.

Reference Data

• RefSeq: NP_861517
• Locus ID: 11065
• UniProt ID: O00762
• Cytogenetics: 20q13.12
• Refseq Size: 901
• Refseq ORF: 540
• Synonyms: dJ447F3.2; UBCH10
• Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013]
• Protein Families: Druggable Genome
• Protein Pathways: Ubiquitin mediated proteolysis