FKBP25 (FKBP3) (NM_002013) Human Recombinant Protein
CAT#: TP721192L
Purified recombinant protein of Human FK506 binding protein 3, 25kDa (FKBP3)
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Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
Met1-Asp224
|
Tag | N-His |
Predicted MW | 27.3 kDa |
Concentration | lot specific |
Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | Supplied as a 0.2 um filtered solution of 20mM Tris-HCl, 1mM DTT, 10% Glycerol, pH 8.0 . |
Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg) |
Storage | Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles. |
Stability | Stable for at least 6 months from date of receipt under proper storage and handling conditions. |
Reference Data | |
RefSeq | NP_002004 |
Locus ID | 2287 |
UniProt ID | Q00688 |
Cytogenetics | 14q21.2 |
Refseq Size | 1353 |
Refseq ORF | 672 |
Synonyms | FKBP-3; FKBP-25; FKBP25; PPIase |
Summary | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008] |
Protein Families | Druggable Genome, Stem cell - Pluripotency |
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