IL23 (p19+p40) Human Recombinant Protein

CAT#: TP723732

Purified recombinant protein of Human interleukin 23 (p19+p40).


  View other "IL23A" proteins (5)

USD 360.00

5 Days*

Size
    • 10 ug

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Specifications

Product Data
Species Human
Expression Host Sf9
Expression cDNA Clone or AA Sequence
Human IL-23 consists of two subunits linked via a disulfide bond: P19, the region of Ala21- Pro189) from Accession# NP_057668, and P40, the region of Ile 23-Ser 328) from Accession# NP_002178.2
Tag Tag Free
Predicted MW 53.3 kDa
Concentration Protein formulated and vialed at >50 ug/mL in specified buffer
Purity >95%, as determined by Coomassie stained SDS-PAGE.
Buffer 1 x PBS
Bioactivity The ED50 is 0.2 - 0.8 ng/ml, corresponding to a specific activity of 5 - 1.25 x 10^6 units/mg determined by mouse splenocyte IL-17A secretion, which is induced by hIL-23 in a dose dependent manner.
Endotoxin Less than 0.01 ng per µg protein as determined by the LAL method
Storage Store at -80°C.
Stability Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Reference Data
RefSeq NP_057668
Locus ID 51561
UniProt ID Q9NPF7
Cytogenetics 12q13.3
Refseq Size 1049
Refseq ORF 567
Synonyms IL-23; IL-23A; IL23P19; P19; SGRF
Summary This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.