BNP (NPPB) (NM_002521) Human Recombinant Protein

CAT#: TP750121

Purified recombinant protein of Human natriuretic peptide B (NPPB), N-terminal His and ABP tag, expressed in E. coli, 50ug

Product Images

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence encoding the region(His27-Arg102) of NPPB
• Tag: N-His-ABP
• Predicted MW: 23.8 kDa
• Concentration: >50 ug/mL as determined by Bradford protein assay method.
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: PBS,pH7.4,10% glycerol
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_002512
• Locus ID: 4879
• UniProt ID: P16860
• Cytogenetics: 1p36.22
• Refseq Size: 708
• Refseq ORF: 402
• Synonyms: BNP
• Summary: 'This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Aug 2020]'
• Protein Families: Druggable Genome, Secreted Protein, Stem cell - Pluripotency