BNP (NPPB) (NM_002521) Human Recombinant Protein

CAT#: TP750121

Purified recombinant protein of Human natriuretic peptide B (NPPB), N-terminal His and ABP tag, expressed in E. coli, 50ug


  View other "NPPB" proteins (4)

USD 215.00

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Size
    • 50 ug

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Specifications

Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
A DNA sequence encoding the region(His27-Arg102) of NPPB
Tag N-His-ABP
Predicted MW 23.8 kDa
Concentration >50 ug/mL as determined by Bradford protein assay method.
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer PBS,pH7.4,10% glycerol
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_002512
Locus ID 4879
UniProt ID P16860
Cytogenetics 1p36.22
Refseq Size 708
Refseq ORF 402
Synonyms BNP
Summary 'This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Aug 2020]'
Protein Families Druggable Genome, Secreted Protein, Stem cell - Pluripotency

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