Cardiac Troponin I (TNNI3) (NM_000363) Human Recombinant Protein
CAT#: TP750154
Purified recombinant protein of Human troponin I type 3 (cardiac) (cTnI), full length, with N-terminal His tag, expressed in E.coli, 100ug
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Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
A DNA sequence encoding human full-length TNNI3
|
Tag | N-His |
Predicted MW | 23.8 kDa |
Concentration | Concentration is determined by spectrophotometrically(A280) |
Purity | > 90% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | Lyophilized from 0.01M HCl,reconstitute with Tris/urea buffer (20mM Tris, pH7.5, 7M Urea, 5mM EDTA, 15mM β-mercaptoethanol). |
Storage | Store at -20°C after receiving vials. |
Stability | Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_000354 |
Locus ID | 7137 |
UniProt ID | P19429, Q6FGX2 |
Cytogenetics | 19q13.42 |
Refseq Size | 2073 |
Refseq ORF | 630 |
Synonyms | CMD1FF; CMD2A; CMH7; cTnI; RCM1; TNNC1 |
Summary | 'Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19. [provided by RefSeq, Aug 2020]' |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Stem cell - Pluripotency |
Protein Pathways | Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM) |
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