P4HA3 (NM_182904) Human Recombinant Protein

CAT#: TP760440

Purified recombinant protein of Human prolyl 4-hydroxylase, alpha polypeptide III (P4HA3), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug


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USD 215.00

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Size
    • 50 ug

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Specifications

Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
A DNA sequence encoding human full-length P4HA3
Tag N-His
Predicted MW 59.3 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_878907
Locus ID 283208
UniProt ID Q7Z4N8
Cytogenetics 11q13.4
Refseq Size 2272
Refseq ORF 1632
Synonyms C-P4H alpha III; collagen prolyl 4-hydroxylase alpha(III); procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III; prolyl 4-hydroxylase, alpha III subunit; prolyl 4-hydroxylase, alpha polypeptide III
Summary This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Protein Families Druggable Genome
Protein Pathways Arginine and proline metabolism, Metabolic pathways

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