PRCP (NM_005040) Human Recombinant Protein
CAT#: TP760531
Purified recombinant protein of Human prolylcarboxypeptidase (angiotensinase C) (PRCP), transcript variant 1, with N-terminal HIS tag, expressed in E.Coli, 50ug
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
A DNA sequence encoding human full-length PRCP
|
Tag | N-His |
Predicted MW | 53.4 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 50mM Tris, 8M Urea, pH8.0. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_005031 |
Locus ID | 5547 |
UniProt ID | P42785, A0A024R5L0 |
Cytogenetics | 11q14.1 |
Refseq Size | 2161 |
Refseq ORF | 1488 |
Synonyms | HUMPCP; PCP |
Summary | 'This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]' |
Protein Families | Druggable Genome, Protease, Transmembrane |
Documents
FAQs |
Resources
Recombinant Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC403704 | PRCP HEK293T cell transient overexpression lysate (as WB positive control) |
USD 155.00 |
|
LC417565 | PRCP HEK293T cell transient overexpression lysate (as WB positive control) |
USD 99.00 |
|
LY403704 | Transient overexpression lysate of prolylcarboxypeptidase (angiotensinase C) (PRCP), transcript variant 2 |
USD 495.00 |
|
LY417565 | Transient overexpression lysate of prolylcarboxypeptidase (angiotensinase C) (PRCP), transcript variant 1 |
USD 325.00 |
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