CISH (NM_145071) Human Recombinant Protein

CAT#: TP761412

Purified recombinant protein of Human cytokine inducible SH2-containing protein (CISH), transcript variant 2, full length, with N-terminal GST and C-terminal HIS tag, expressed in E. coli, 50ug


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USD 215.00

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Size
    • 50 ug

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Specifications

Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
A DNA sequence encoding human full-length CISH
Tag N-GST and C-His
Predicted MW 56.5 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25mM Tris,pH8.0,150mM NaCl,10% glycerol,1% Sarkosyl.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_659508
Locus ID 1154
UniProt ID Q9NSE2
Cytogenetics 3p21.2
Refseq Size 2035
Refseq ORF 774
Synonyms BACTS2; CIS; CIS-1; G18; SOCS
Summary 'The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]'
Protein Families Druggable Genome
Protein Pathways Jak-STAT signaling pathway

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