IBRDC2 (RNF144B) (NM_182757) Human Recombinant Protein

CAT#: TP761424

Purified recombinant protein of Human ring finger protein 144B (RNF144B), full length, with N-terminal GST and C-terminal HIS tag, expressed in E. coli, 50ug

Product Images

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence encoding human full-length RNF144B
• Tag: N-GST and C-His
• Predicted MW: 61.5 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25mM Tris,pH8.0,150mM NaCl,10% glycerol,1% Sarkosyl.
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_877434
• Locus ID: 255488
• UniProt ID: Q7Z419
• Cytogenetics: 6p22.3
• Refseq Size: 4782
• Refseq ORF: 4811
• Synonyms: bA528A10.3; IBRDC2; p53RFP; PIR2
• Summary: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se. [UniProtKB/Swiss-Prot Function]
• Protein Families: Transmembrane