C3IP1 (KLHL12) (NM_021633) Human Recombinant Protein

CAT#: TP761437

Purified recombinant protein of Human kelch-like 12 (Drosophila) (KLHL12), full length, with N-terminal GST and C-terminal HIS tag, expressed in E. coli, 50ug

Product Images

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence encoding human full-length KLHL12
• Tag: N-GST and C-His
• Predicted MW: 91.1 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25mM Tris,pH8.0,150mM NaCl,10% glycerol,1% Sarkosyl.
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_067646
• Locus ID: 59349
• UniProt ID: Q53G59, Q9H7R2
• Cytogenetics: 1q32.1
• Refseq Size: 3338
• Refseq ORF: 1704
• Synonyms: C3IP1; DKIR
• Summary: This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]