DUSP10 (NM_144729) Human Recombinant Protein

CAT#: TP761617

Purified recombinant protein of Human dual specificity phosphatase 10 (DUSP10), transcript variant 3, full length, with N-terminal GST and C-terminal HIS tag, expressed in E. coli, 50ug

Product Images

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Tag: N-GST and C-His
• Predicted MW: 43.9 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25mM Tris, pH8.0,150mM NaCl,10% glycerol,1%Sarkosyl.

Reference Data

• RefSeq: NP_653330
• Locus ID: 11221
• Cytogenetics: 1q41
• Refseq Size: 1824
• Refseq ORF: 1449
• Synonyms: MKP-5; MKP5
• Summary: Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
• Protein Families: Druggable Genome, Phosphatase
• Protein Pathways: MAPK signaling pathway