GBA (NM_001005741) Human Recombinant Protein

CAT#: TP761812

Purified recombinant protein of Human glucosidase, beta, acid (GBA), transcript variant 2, full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug


  View other "GBA" proteins (17)

USD 215.00

In Stock*

Size
    • 50 ug

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Specifications

Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
A DNA sequence encoding human full-length GBA
Tag N-GST and C-His
Predicted MW 83.5 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50mM Tris, pH8.0,8M Urea.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_001005741
Locus ID 2629
UniProt ID P04062, B7Z6S9, A0A068F658
Cytogenetics 1q22
Refseq Size 2583
Refseq ORF 1608
Synonyms GBA1; GCB; GLUC
Summary 'This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]'
Protein Families Druggable Genome
Protein Pathways Lysosome, Metabolic pathways, Other glycan degradation, Sphingolipid metabolism

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