Hamartin (TSC1) (NM_000368) Human Recombinant Protein

CAT#: TP762028

Purified recombinant protein of Human tuberous sclerosis 1 (TSC1), transcript variant 1,Ser836-His1164, with N-terminal His tag, expressed in E. coli, 50ug


  View other "TSC1" proteins (2)

USD 215.00

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Size
    • 50 ug

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Specifications

Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
A DNA sequence encoding the region(Ser836-His1164) of TSC1
Tag N-His
Predicted MW 36.6 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol,1% Sarkosyl.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_000359
Locus ID 7248
UniProt ID Q92574, Q86WV8, X5D9D2
Cytogenetics 9q34.13
Refseq Size 8617
Refseq ORF 443
Synonyms LAM; TSC
Summary 'This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signalling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including Tsc2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis. [provided by RefSeq, Apr 2018]'
Protein Pathways Insulin signaling pathway, mTOR signaling pathway

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